Effect of cross-linked biodegradable polymers on sustained release of sodium diclofenac-loaded microspheres
نویسندگان
چکیده
منابع مشابه
Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers
Controlled drug delivery technology of proteins/peptides from biodegradable nanoparticles has emerged as one of the eminent areas to overcome formulation associated problems of the macromolecules. The purpose of the present investigation was to develop protein-loaded nanoparticles using biodegradable polymer poly L-lactide-co-glycolidic acid (PLGA) with bovine serum albumin (BSA) as a model pro...
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Sustained release of thermal-instable and water-soluble drugs with low molecule weight is a challenge. In this study, sodium bicarbonate was encapsulated in ethyl cellulose microspheres by a novel solid-in-oil-in-oil (S/O/O) emulsification method using acetonitrile/soybean oil as new solvent pairs. Properties of the microspheres such as size, recovery rate, morphology, drug content, and drug re...
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Sustained release of thermal-instable and water-soluble drugs with low molecule weight is a challenge. In this study, sodium bicarbonate was encapsulated in ethyl cellulose microspheres by a novel solid-in-oil-in-oil (S/O/O) emulsification method using acetonitrile/soybean oil as new solvent pairs. Properties of the microspheres such as size, recovery rate, morphology, drug content, and drug re...
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Object: The objective of the present study was to investigate the effect of various concentrations of natural and synthetic polymers on in vitro drug release from sustained release matrix tablets. Materials and method: HPMC K4M and acacia gum were used as synthetic (hydrophilic) and natural (hydrophobic) polymers respectively. Diclofenac sodium was used as a model drug to study the in vitro rel...
متن کاملSustained Release of VEGF from Gadolinium Doped Biodegradable Microspheres
Biodegradable microspheres are effective devices for controlled drug release, and it is desireable to be able to monitor their distribution in vivo in order to optimize delivery methods. Biodegradable microspheres coencapsulating Gd-DTPA and human vascular endothelial growth factor (VEGF) were made from poly(1actic-co-glycolic acid) (PLGA). The release of VEGF from the spheres was measured and ...
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2013
ISSN: 1984-8250
DOI: 10.1590/s1984-82502013000400028